Metabolism Ketamine is metabolized by means of N-dealkylation into the Lively metabolite norketamine mainly by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation of your cyclohexone ring to variety hydroxynorketamine compounds through CYP-dependent pathways, which are conjugated with glucuronic acid